The Biomedical Neuroscience Institute (www.bni.cl) and the Geroscience Center for Brain
Health and Metabolism (www.gerochile.cl) are seeking a highly-qualified and motivated
applicant for a full time postdoctoral position at the laboratory of Proteostasis Control and
Biomedicine of the University of Chile
Post-Doc Position:
This position funded by national grants project for a 3 year period. Starting date: For March
2020 or later upon agreement.
Project: The project is part of a larger initiative involving collaboration with different labs in the
US, Europe and Chile. This laboratory focuses on understanding the molecular basis of
proteostasis control and its relationship to pathological conditions affecting the nervous system.
The project aims to the study cellular strategies involved in adaptation to chronic endoplasmic
reticulum (ER) stress. The ER has important cellular functions, highlighting its role as
sophisticated machinery for protein folding and secretion. ER stress engages an integrated
signaling pathway known as the “Unfolded Protein Response” (UPR), which aims to restore
homeostasis. Nevertheless, the mechanisms that control the transition from an adaptive state to
cell death processes remain unknown and is a central subject of our research. We are currently
developing a systematic approach to underscore the effects of targeting the UPR in several
brain diseases. He/she investigates signal transduction pathways regulating stress pathways
(UPR, autophagy and apoptosis). Furthermore, he/she supports the Chair in teaching and
student supervision.
Qualifications: Candidates are expected to hold a PhD in Biology or similar education,
preferentially with several years of experience. Furthermore, a strong practical and theoretical
background and experience in protein biochemistry, cell biology, molecular biology and/or
animal experimentation is of advantage. Good English language skills required.
Complete applications, including CV, publication list and 2 references should be submitted to
Dr. Claudio Hetz (chetz@med.uchile.cl) or call +56 (2) 29786506. Website: www.hetzlab.cl
